Fisetin is a naturally occurring flavonol and in particular a flavonoid polyphenol. Fisetin can be found in some fruits and vegetables, which includes apples, strawberries, onions, persimmon, and cucumbers. Fisetin is surprisingly unknown compared to the other famous plant antioxidants, such as resveratrol and quercetin. More recently scientists have became increasingly interested in the medicinal potential of fisetin. Right now there is an interest in examining the ability of the polyphenol to slow down the aging process and extend the lifespan in humans, which is also known as the senolytic effect.
Other research have shown fisetin has potent anti-inflammatory and antioxidant effects, can protect the brain and improve memory, may support controlling the blood sugar levels, may protect the liver and heart, and could have anticancerigen properties.
- Preclinical studies suggest that fisetin may strengthen the connections between brain cells and enhance memory in healthy rodents. In addition, studies of Alzheimer’s disease in animals suggest fisetin may lower levels of aggregated beta-amyloid and phosphorylated tau, lower levels of neuroinflammation, and prevent the development of memory deficits.
- One recent scientific study tested 10 flavonoids for the effect on extending the life-span in rodents. Fisetin came out at the top as the most potent senolytic. Fisetin reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity. Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.
Take 1/2 to 2 teaspoons daily.
The various effects are not guaranteed and results may vary due to several factors between different people.
We strive to ensure the accuracy of the information provided by the manufacturers and recommend that you read all labels and warnings. However, the information is not a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment.
Reviewers have not been compensated for their testimonials. Reviews in other languages than English are automatically translated.