Fisetin powder is a naturally occurring flavonoid polyphenol found in certain fruits and vegetables, such as strawberries (160 mg/kg), apples (30 mg/kg), onions, cucumbers, and persimmons. The compound is still largely unknown compared to several widely known antioxidants, such as resveratrol. More recently it has garnered interest from scientists for the medicinal potential. Particularly there is an interest in studying the ability of the polyphenol to slow the aging process and extend animal lifespans, which is called the senolytic effect. This beneficial potential of the antioxidant is exciting as the polyphenol is classified as a dietary supplement and thus readily available to most people.
Other research have shown the biochemical has potent anti-inflammatory and antioxidant effects, can protect the brain, supports controlling the blood sugar levels, can build bone strength, can help protect the liver and heart, and could have anticancerigen properties. It appears that it supports improved neural communication, which in turn boosts cognitive processes and memory function.
- Preclinical studies suggest that fisetin powder may strengthen the connections between brain cells and enhance memory in healthy rodents. In addition, studies of Alzheimer’s disease in animals suggest the compound may lower levels of aggregated beta-amyloid and phosphorylated tau, lower levels of neuroinflammation, and as a prophylactic during the development of memory deficits.
- One recent scientific study tested ten flavonoids for the effect on extending the life-span in rodents. Fisetin came out at the top as the most potent senolytic. The flavonol reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity. Administration of the polyphenol to mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.
There recommended daily amount is 200 mg to 1500 mg.
Fisetin powder 99% extract powder. The appearance is pale to yellow.
The various effects are not guaranteed and results may vary due to several factors between different people.
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