Description
Organic Gynostemma Pentaphyllum Supplement (Jiaogulan) is an Asian plant with a wide range of potential health benefits. It is also known as Gynostemma Pentaphyllum and it is reputed to have powerful antioxidant and adaptogenic effects. Jiaogulan is actively being studied for its potential effects on the AMP-activated protein kinase (AMPK) pathway.
AMPK is an enzyme that plays a crucial role in regulating cellular energy balance, metabolism, and various physiological processes. The activation of the AMPK pathway can stimulate glucose uptake, enhance mitochondrial function, and promote energy expenditure. The positive metabolic effects by AMPK activation relates to blood sugar regulation, lipid metabolism, and overall metabolic balance.
The anti-diabetic effect is possibly mediated by the activation of AMPK and the inhibition of PTP1B. Other effects appears to be from antioxidant enzymes that protects cells from oxidative damage over time.
Function
People take the organic gynostemma pentaphyllum supplement for a variety of reasons.
- Anti-Inflammatory Antioxidant. Jiaogulan is rich in antioxidants, which can help combat oxidative stress and reduce the risk of chronic diseases. Antioxidants also support healthy aging and protect cells from damage. The reduced inflammation in the body is associated with various chronic diseases, including arthritis and inflammatory conditions
- Mitochondrial Function. AMPK activation by gynostemma promotes mitochondrial biogenesis, the process by which new mitochondria are formed within cells. Mitochondria are the cellular organelles responsible for generating ATP through oxidative phosphorylation. By increasing mitochondrial density and function, it supports cellular energy production and overall metabolic health.
- Heart Function. Jiaogulan has been linked to several cardiovascular benefits, including the potential to lower blood pressure, reduce LDL cholesterol levels, and improve overall heart health. A key mechanism is that jiaogulan activates AMPK, which inhibits lipid synthesis and promotes fatty acid oxidation in the liver and skeletal muscle. This leads to reduced lipid accumulation and improved lipid profile, contributing to cardiovascular health management.
- Weight Management. Some individuals have reported weight loss or weight management benefits when using gynostemma extract, possibly due to the effect of actiponin on metabolism and appetite regulation. Studies suggest that actiponin may promote the breakdown of fat stores and the utilization of stored fat for energy expenditure.
- Stress Reduction and Adaptogenic Effects. Jiaogulan is classified as an adaptogen, meaning it helps the body adapt to stressors and maintain homeostasis. Chronic stress accelerates aging by promoting oxidative damage, inflammation, and dysregulation of cellular processes. Jiaogulan’s adaptogenic properties may mitigate the detrimental effects of stress on cellular aging and support resilience against age-related stressors.
- Energy and Stamina. Gynostemma extract may increase energy levels and physical endurance by several mechanisms. First by improving mitochondrial function, which are the powerhouses of cells responsible for generating energy in the form of adenosine triphosphate (ATP). Second by improving oxygen delivery to tissues and enhancing cellular respiration, it can help boost endurance and stamina, particularly during physical activity.
- Aging. Jiaogulan contains various phytochemicals, including flavonoids, saponins, and polyphenols, which exhibit potent antioxidant properties. These compounds help neutralize harmful free radicals in the body, which are implicated in oxidative stress and aging-related processes such as cellular damage, inflammation, and DNA mutations. The herbal has also been shown to possess anti-inflammatory properties by inhibiting pro-inflammatory cytokines and signaling pathways. By reducing inflammation, it can help mitigate age-related inflammatory conditions and promote overall health.
- Antitumor Potential. Some studies suggest that gynostemma pentaphyllum may enhance immune function by increasing the activity of natural killer (NK) cells, T cells, and macrophages, which play crucial roles in identifying and destroying cancer cells. By enhancing immune surveillance, it may help the body recognize and eliminate cancerous cells. In addition, it has been reported to induce apoptosis in various cancer cell lines, triggering their death and inhibiting tumor growth. Lastly gynostemma can inhibit angiogenesis which can limit the blood supply to tumors and impeding their growth.
Suggested use
The suggested dose is 1 to 2 capsules a day.
Ingredients
Organic Gynostemma Pentaphyllum Supplement (Jiaogulan). Contains concentrated 20:1 extract. Capsule weight: 500 mg. Vegetarian capsules made from cellulose.
Disclaimer
The various effects are not guaranteed and results may vary due to several factors between different people.
We strive to ensure the accuracy of the information provided by the manufacturers and recommend that you read all labels and warnings. However, the information is not a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment.
