Contents
- β-Nicotinamide Mononucleotide (NMN)
- Nicotinamide Riboside (NR, NR-Cl)
- Nicotinamide Adenine Dinucleotide (NAD+, NADH)
- Resveratrol
- Pterostilbene
- Fisetin
- Apigenin
- Quercetin
- Rutinoside / Rutin
- Curcumin
- Berberine
- Metformin
- Lutein / Zeaxanthin
- Astaxanthin
- Anthocyanins
- Oligomeric Proanthocyanidins (OPC)
- EGCG (Epigallocatechin Gallate)
- Luteolin
- Allicin
- Lycopene
- L-Glutathione (Reduced Glutathione, GSH)
- Cycloastragenol (CAG)
- Sulforaphane
- Indole-3-Carbinol (I3C)
- AHCC (Active Hexose Correlated Compound)
- Milk Thistle (Silymarin)
- Reduced Coenzyme Q10 (CoQ10, Ubiquinol)
- Pyrroloquinoline Quinone (PQQ)
- Hydrolyzed Marine Collagen
- Omega-3 (EPA, DHA, ALA)
- Eucommia
Natural NMN (nicotinamide mononucleotide)
1. NMN (β-Nicotinamide Mononucleotide)
Nicotinamide mononucleotide (NMN, β-NMN) is a nucleotide composed of vitamin B3 (nicotinamide), a sugar molecule (ribose), and a phosphate molecule. Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide (NADH). In mice, NMN enters cells via the small intestines within 10 minutes converting to NAD+ through the Slc12a8 NMN transporter.
NAD+ levels decline with age, and this decline is thought to be associated with accelerated physical decline and the onset of age-related diseases like Alzheimer’s. Animal studies have shown that supplementing with NAD+ precursors NMN and NR restores NAD+ levels and prevents age-related physical decline. NAD+ is a compound found in every cell in your body and involved in many critical processes, including energy metabolism, DNA repair, and gene expression. NMN supplementation in turn has prevented age-associated genetic changes and improved energy metabolism, physical activity, and insulin sensitivity.
Because NADH is a cofactor for processes inside mitochondria, for sirtuins, and for PARP, NMN has been studied in animal models as a potential neuroprotective and anti-aging agent.
NMN can be given safely to mice and is found naturally in a number of foods, including broccoli, cabbage, cucumber, edamame and avocado. The new study shows that when NMN is dissolved in drinking water and given to mice, it appears in the bloodstream in less than three minutes. Importantly, the researchers also found that NMN in the blood is quickly converted to NAD in multiple tissues.
In skeletal muscle NMN administration helps energy metabolism by improving the function of mitochondria, which operate as cellular power plants. They also found that mice given NMN gained less weight with aging even as they consumed more food, likely because their boosted metabolism generated more energy for physical activity.
Benefits
Slowed pace of aging. NMN is quickly absorbed and converted to NAD when administered orally, which several studies have shown increases NAD levels, decreases inflammation in aging adipose tissue, increases insulin secretion and action, enhances mitochondrial function, enhances brain neuronal function, and more.
Longer lifespan. There are several studies that show lifespan is extended in mice, while longer studies on humans are ongoing.
Muscle growth. One study published found that people who consumed a NMN after resistance training experienced 22 percent more muscle protein synthesis than a control group. NMN was also effective at reducing the breakdown of muscle in the body in humans, for example from side effect of chronic conditions like cancer or normal part of the aging process. Recent research on amateur runners showed that an increased exercise-induced human aerobic capacity when using NMN.
Metabolic diseases. Animal research have revealed promising findings concerning the function of NAD boosters in reversing the effects of high-fat diets, reducing body weight, and enhancing energy levels. According to the findings of a small clinical study, women with prediabetes who took NMN for 10 weeks had better muscle glucose metabolism.
Energy and stamina. Although there isn’t much clinical proof for this advantage, studies on mice reveal that NMN can boost stamina and endurance by up to 80%.
Cognitive function. Studies on rodents back up the idea that NMN enhances a number of crucial mental processes, including cognition and memory in models of Alzheimer’s disease.
Side-effects
There are no documented negative effects of NMN. Numerous studies have demonstrated that even at extremely large doses of NMN administered to mice there are no harmful or adverse consequences. According to human clinical toxicity study at Keio University in Japan, NMN can be supplied safely and is efficiently digested in the body.
2. NR (Nicotinamide Riboside)
Nicotinamide riboside (NR, NR-Cl) is a slightly smaller molecule to NMN, as it composed only of vitamin B3 (nicotinamide or niacin) and a sugar molecule (ribose). This vitamin B3 substance is known by the name niagen.
The body transforms nicotinamide riboside into nicotinamide adenine dinucleotide (NAD), a coenzyme or helper molecule, much like it does with other forms of vitamin B3. Many important biological activities, including the following, use NAD as fuel:
- Repairing damaged DNA
- Enhancing cell defense mechanisms
- transforming food into energy
- regulating the circadian rhythm
However, as you age, your body’s natural level of NAD declines. At this time, chronic diseases occur with lowered NAD levels, such as diabetes, heart disease, Alzheimer’s disease, and eyesight loss. Interestingly, animal studies have discovered that increasing NAD levels may help prevent many chronic diseases and reverse indications of aging.
Natural sources of NR are cow’s milk, yeast, and beer, but they only contain trace levels of niacin. Nicotinamide riboside supplements have swiftly gained popularity, as they seem to be particularly successful at increasing NAD levels.
Benefits
Nicotinamide riboside increases blood NAD levels by up to 2.7 times, according to animal studies. Additionally, compared to other NAD precursors, it is utilised by your body more quickly.
NAD activates enzymes that repair DNA damage and supports healthy aging. Sirtuins are one such family that seems to extend the life span of animals and enhance general health. Studies show that sirtuins may restore DNA damage, increase stress resistance, lessen inflammation, and provide other advantages that support healthy aging. (Notably, the advantages of calorie restriction for increasing lifespan are also due to sirtuins.)
Another category of enzymes that restores DNA damage are Poly (ADP-Ribose) polymerases (PARPs). Higher PARP activity has been linked in studies to reduced DNA damage and a longer life span.
NAD may help protecting the brain and neurons. Researchers think that age-related brain illnesses including Alzheimer’s and Parkinson’s disease are associated with both oxidative stress and decreased mitochondrial activity.
NAD aids in the regulation of PGC-1-alpha synthesis in brain cells, a protein that appears to help shield cells against oxidative stress and compromised mitochondrial function. NR increased brain NAD+ levels and PGC-1-alpha synthesis in Alzheimer’s disease-affected mice by up to 70% and 50%, respectively. By the end of the experiment, the mice significantly outperformed the humans in memory-based activities.
In a study using stem cells from a Parkinson’s patient, nicotinamide riboside increased NAD+ levels and markedly enhanced mitochondrial performance.
Reduced risk for heart disease. Coronary disease is the largest cause of death worldwide and heavily influenced by aging. Your aorta, for example, may become thicker, stiffer, and less flexible as a result. These alterations can increase blood pressure and put more strain on your heart.
NR increased NAD levels in humans, assisted in reducing aortic stiffness, and decreased systolic blood pressure in people at risk of high blood pressure. NR have also helped mice increase their metabolism, which may help with weight loss.
Anticancer. High NAD levels aid in the prevention of oxidative stress and DNA damage, which are connected to the development of cancer.
Side-effects
The observed side-effects of NR are small. Studies on humans find that taking 1-2 gram daily has no harmful effects. Mild to moderate side effects for some people, include as headaches, fatigue, diarrhea, and nausea.
3. Nicotinamide Adenine Dinucleotide (NAD+, NADH)
Nicotinamide Adenine Dinucleotide exists in two forms: NAD+ and NADH. The difference is that NAD+ is a positive charged ion, while NADH has an hydrogen atom attached to the molecule. They are produced by the body naturally and help to provide our cells with energy.
People use NADH for a variety of ailments, including Parkinson’s disease, depression, high blood pressure, high cholesterol, sports performance, and chronic fatigue syndrome (CFS), but scientific evidence are still lacking.
A problem with supplementing with NAD+ and NADH is that the molecule easily deteriorates when exposed to water, light, and heat. According to a study published in the Journal of Nutritional Science and Vitaminology, oral administration of NAD+ breaks down into common precursors before the cells have a chance to absorb it.
4. Resveratrol
Resveratrol is often cited as a one explanation for the French Paradox, which refers to the surprisingly low prevalence of coronary heart disease in France. Resveratrol, which is found in the skin and seeds of red wine grapes, is a key to the conundrum.
Resveratrol is a polyphenol that is produced especially within stressed plants. It is a defense mechanism produced by plants to ward off fungi, defend themselves from dehydration, or shield themselves from harmful UV radiation. This type stress response phenomena in organisms has been called hormesis.
Benefits
The benefits of resveratrol are numerous and astounding and includes it being anti-inflammatory, anti-carcinogenic, cardioprotective, and neuroprotective. It has been used to treat blood pressure, stomachaches, hepatitis, arthritis, urinary tract infections, fungal disorders, and skin irritation, according to one peer-reviewed article.
Numerous studies indicate that resveratrol has a wide range of physiological effects on people. The strong antioxidant properties comes from the capacity to function as both a direct antioxidant and as what researchers refer to as an indirect cellular antioxidant system inducer is largely responsible for the amazing potential that numerous studies have shown in this area. In other words, it is actively scavenging free radicals and defending cells from oxidative stress on several levels. Reduced blood pressure and a decreased risk of age-related cognitive decline are positive side effects of resveratrol antioxidant qualities, while additional research is need to draw firm conclusions.
Resveratrol may also be a useful substance for the management and prevention of a number of cancer types, e.g. breast cancer. It functions at each of the three stages of carcinogenesis, or the process by which healthy cells develop cancer, by altering the pathways that regulate cell division and proliferation. Additionally, it may interfere with the expression of some hormones, which could prevent the spread of hormone-dependent tumors, and it can affect the gene expression in cancer cells, which slows down the growth of these cells. Although further clinical trials are required, what is known thus far is quite intriguing.
Resveratrol may have cardioprotective benefits. It uniquely seem to be beneficial for several conditions connected to cardiovascular disease and heart failure.
Perhaps the most important effect is the potential of resveratrol to activate sirtuins, a family of seven protein enzymes intimately linked to cellular health regulation and lifespan in animals. Resveratrol specifically activates the SIRT-1 sirtuin, a mechanism that has an antioxidant effect, increased insulin resistance, and support for the musculoskeletal and neurological systems. Resveratrol is a key component of the it is a powerful polyphenol that has likely undergone the most investigation of all the known sirtuin enhancers.
Side-effects
Resveratrol does not have considerable side-effects at typical doses (1-2 grams). However, it does have a moderate blood thinning effect, may lower blood pressure, and can slow blood clotting. Because of these effects you should speak with your doctor if you are taking blood thinning medications or if you are scheduled for a surgery.
5. Pterostilbene
Pterostilbene is a naturally occurring polyphenol in some plants, such as blueberries. It is a stilbenoid like resveratrol, but it has a higher bioavailability and adsorption rate. The general benefits according to research is that it is anti-inflammatory, antioxidant, blood-sugar-balancing, anticarcinogenic, pain-relieving, cardiovascular-/neurological- protective properties.
Benefits
Antioxidant. Pterostilbene has been demonstrated to aid in lowering free radical damage, just like vitamin C and vitamin E. According to the published studies, pterostilbene has direct antioxidant actions and increases the body’s natural antioxidant defenses and enzymes. Several of its prospective health benefits are thought to be connected to its antioxidant properties.
Anti-Inflammatory. Numerous chronic diseases have been linked to an increase in inflammatory activity within the body. A signaling chemical called nitric oxide can contribute to immunological responses by inducing inflammation. Aspirin and ibuprofen both suppress the inflammatory signaling molecule cyclooxygenase (COX). The anti-inflammatory effect of pterostilbene appears to block both of these signaling molecules. Multiple chronic disorders have been linked to elevated levels of these enzymes.
Neuroprotective. The prevalence of Alzheimer’s disease has been rising as the life-span increase. Currently, Alzheimer’s disease causes a slow, irreversible deterioration that eventually results in memory loss, disability, and death, even with routine therapy. Unfortunately, there are no approved medications that can change the course of a disease.
A new strategy is using supplements, e.g. acetyl-L-carnitine, omega-3, citicoline, and pterostilbene in the prevention or treatment. In one study, involving older rats found pterostilbene to be effective in reversing age-related cognitive deterioration, such as memory gains.
One crucial neurotransmitter that declines with dementia is acetylcholine. However, studies have found pterostilbene slows down the metabolism and breakdown of acetylcholine and thus preventing the deterioration. These results have been replicated by several animal research using various models, which have revealed enhanced memory function, elevated acetylcholine levels, and improving brain inflammation.
Heart health. Pterostilbene also seems to aid in heart disease prevention through a number of the previously mentioned mechanisms, such as antioxidant and anti-inflammatory actions. Again, research has shown that pterostilbene protects the heart from harm or enhances cardiac function, even in the midst of acute heart failure or following a heart attack. Pterostilbene may have potential blood pressure-lowering effects, according to preliminary human experiments. Pterostilbene may exhibit considerable heart advantages with further human clinical trials, just as a variety of other natural substances, such as CoQ10, carnitine, and garlic extract.
Blood sugar. Several organic substances seem to have potential for regulating blood sugar and assisting in the treatment of diabetes. Among other natural substances, cinnamon, berberine, and hibiscus have all demonstrated potential advantages. Recent research on pterostilbene shows great promise for assisting with blood sugar control and diabetes problems.
Animal studies clearly support the potential advantages for diabetes by using pterostilbene. In some of the earlier studies, rodents with diabetes that were given pterostilbene exhibited blood sugar-lowering effects similar to that of the diabetic drug metformin.
Pterostilbene additionally has a number of preventive benefits for diabetes. It prevents kidney damage, which is one of the major complication in diabetes. Pterostilbene applied topically can speed up the duration of burn healing. Likewise, it has been demonstrated that it can help prevent hearing loss in diabetic rodents by reducing free-radical damage.
Obesity. The body has a form of fat called brown adipose tissue, which is metabolically active and burns calories to produce heat. By contrast, the white adipose tissue is the fat tissue linked to weight growth and obesity. It has been demonstrated that pterostilbene increases the caloric intake of brown adipose tissue in animal models. It has been shown that pterostilbene helps the white adipose tissue to act more like brown adipose tissue and burn extra calories.
Pterostilbene has been found to prevent the growth of new fat cells and the adsorption of fat into white adipose tissue. Inflammation is also known to rise with obesity. Inflammatory signaling molecules are produced by fat cells, and this results in excessive inflammation throughout the body. Pterostilbene aids in preventing this inflammatory signaling from fat cells because of its anti-inflammatory properties.
The advantages for gut flora also seem to apply to obesity. It is overall recognized that some alterations in gut flora may promote weight gain. The effects of pterostilbene on gut flora restoration appear to contribute to the management of obesity. Animal experiments shows to rectify the gut flora abnormalities prevalent in overweight animals.
Pain-relief. Large human clinical trials are lacking, but the anti-inflammatory properties suggests it could function as a pain relief. A study on rodents with arthritis demonstrated decreased edema and inflammation. Pterostilbene also altered the composition of the gut flora, reducing harmful bacteria in the digestive tract, which could aid in reducing inflammation. Another rodent study showed improvement in rheumatoid arthritis when pterostilbene was paired with physical activity.
Side-effects
Pterostilbene is regarded as safe up to levels of 250 mg per day. Although, some people may notice an increase in LDL cholesterol. With supplement doses that are higher than what is typically consumed through diet, general caution is advised.
6. Fisetin
Fisetin is a naturally occurring flavonoid found in many fruits and vegetables, such as strawberries, apples, and onions. It has gained attention in recent years for its potential health benefits, including its antioxidant and anti-inflammatory properties.
Strawberries contains naturally fisetin
Fisetin is a naturally occurring flavonoid with several potential health benefits, including its antioxidant and anti-inflammatory properties, potential to support brain and cardiovascular health, and potential to improve skin health.
Benefits
Antioxidant. Fisetin has been found to have antioxidant properties, which can help to protect the body against damage from free radicals. Free radicals can contribute to the development of chronic diseases such as cancer, heart disease, and Alzheimer’s disease.
Anti-inflammatory. Fisetin has been found to have anti-inflammatory properties, which can help to reduce inflammation in the body. Chronic inflammation is a common factor in the development of many diseases.
Brain health. Fisetin has been found to have neuroprotective properties and may help to improve cognitive function. It has been studied as a potential treatment for Alzheimer’s disease and other neurodegenerative diseases.
Cardiovascular health. Fisetin has been found to have cardioprotective properties and may help to reduce the risk of heart disease. It has been studied as a potential treatment for high blood pressure and atherosclerosis.
Skin health. Fisetin has been found to have anti-aging properties and may help to improve skin health. It has been studied as a potential treatment for age-related skin conditions such as wrinkles and age spots.
Side-effects
While there have been some studies on the potential health benefits of fisetin, more research is needed to confirm these benefits and determine optimal dosages and safety.
Some people may experience side effects from fisetin supplements, including digestive upset, headaches, and allergic reactions. It is important to talk to your healthcare provider before using fisetin if you have any health conditions or are taking any medications.
Fisetin may interact with some medications, including blood thinners and medications for diabetes. If you are taking any medications, it is important to talk to your healthcare provider before using fisetin.
As with many natural supplements, there can be issues with quality control and consistency of dosages in fisetin supplements. It is important to choose a high-quality supplement from a reputable source to minimize this risk.
Fisetin supplements are not recommended for use during pregnancy or breastfeeding due to a lack of safety data.
7. Apigenin
Apigenin is a naturally occurring flavonoid found in many fruits, vegetables, and herbs, such as celery, parsley, and chamomile. It has gained attention in recent years for its potential health benefits, including its antioxidant and anti-inflammatory properties.
Apigenin is a naturally occurring flavonoid with several potential health benefits, including its antioxidant and anti-inflammatory properties, potential to support brain and cardiovascular health, and potential to inhibit the growth and spread of cancer cells.
Benefits
Antioxidant. Apigenin has been found to have antioxidant properties, which can help to protect the body against damage from free radicals. Free radicals can contribute to the development of chronic diseases such as cancer, heart disease, and Alzheimer’s disease.
Anti-inflammatory. Apigenin has been found to have anti-inflammatory properties, which can help to reduce inflammation in the body. Chronic inflammation is a common factor in the development of many diseases.
Brain health. Apigenin has been found to have neuroprotective properties and may help to improve cognitive function. It has been studied as a potential treatment for Alzheimer’s disease and other neurodegenerative diseases.
Cardiovascular health. Apigenin has been found to have cardioprotective properties and may help to reduce the risk of heart disease. It has been studied as a potential treatment for high blood pressure and atherosclerosis.
Anticancer. Apigenin has been found to have potential anticancer properties, which can help to inhibit the growth and spread of cancer cells. It has been studied as a potential treatment for various types of cancer, including breast, colon, and prostate cancer.
Side-effects
While there have been some studies on the potential health benefits of apigenin, more research is needed to confirm these benefits and determine optimal dosages and safety.
Some people may experience side effects from apigenin supplements, including digestive upset, headaches, and allergic reactions. It is important to talk to your healthcare provider before using apigenin if you have any health conditions or are taking any medications.
Apigenin may interact with some medications, including blood thinners and medications for anxiety and depression. If you are taking any medications, it is important to talk to your healthcare provider before using apigenin.
As with many natural supplements, there can be issues with quality control and consistency of dosages in apigenin supplements. It is important to choose a high-quality supplement from a reputable source to minimize this risk.
Apigenin supplements are not recommended for use during pregnancy or breastfeeding due to a lack of safety data.
8. Quercetin
Quercetin is a flavonoid found in many fruits and vegetables, including onions, apples, and berries. It has gained attention in recent years for its potential health benefits, including its antioxidant and anti-inflammatory properties.
Quercetin is a flavonoid with several potential health benefits, including its antioxidant and anti-inflammatory properties, potential to support cardiovascular health and immune system function, and potential to inhibit the growth and spread of cancer cells.
Benefits
Antioxidant. Quercetin has been found to have antioxidant properties, which can help to protect the body against damage from free radicals. Free radicals can contribute to the development of chronic diseases such as cancer, heart disease, and Alzheimer’s disease.
Anti-inflammatory. Quercetin has been found to have anti-inflammatory properties, which can help to reduce inflammation in the body. Chronic inflammation is a common factor in the development of many diseases.
Cardiovascular system. Quercetin has been found to have cardioprotective properties and may help to reduce the risk of heart disease. It has been studied as a potential treatment for high blood pressure and atherosclerosis.
Immune system. Quercetin has been found to have immunomodulatory properties and may help to support immune system function. It has been studied as a potential treatment for allergies and other immune system disorders.
Anticancer. Quercetin has been found to have potential anticancer properties, which can help to inhibit the growth and spread of cancer cells. It has been studied as a potential treatment for various types of cancer, including breast, colon, and prostate cancer.
Side-effects
Quercetin has limited bioavailability, meaning that the body may not absorb it well. This can make it difficult to achieve therapeutic levels of quercetin through dietary sources alone.
Some people may experience side effects from quercetin supplements, including digestive upset, headaches, and allergic reactions. It is important to talk to your healthcare provider before using quercetin if you have any health conditions or are taking any medications.
Quercetin may interact with some medications, including blood thinners and medications for anxiety and depression. If you are taking any medications, it is important to talk to your healthcare provider before using quercetin.
Quercetin supplements are not recommended for use during pregnancy or breastfeeding due to a lack of safety data.
9. Rutin
Rutin (rutoside, rutinoside) is a flavonoid found in many fruits, vegetables, and herbs, including buckwheat, citrus fruits, and Ginkgo biloba. It has been studied for its potential health benefits, including its antioxidant and anti-inflammatory properties.
Rutin is a flavonoid with several potential health benefits, including its antioxidant and anti-inflammatory properties, potential to support cardiovascular health, cognitive function, and inhibit the growth and spread of cancer cells.
Benefits
Antioxidant. Rutin has been found to have antioxidant properties, which can help to protect the body against damage from free radicals. Free radicals can contribute to the development of chronic diseases such as cancer, heart disease, and Alzheimer’s disease.
Anti-inflammatory. Rutin has been found to have anti-inflammatory properties, which can help to reduce inflammation in the body. Chronic inflammation is a common factor in the development of many diseases.
Cardiovascular health. Rutin has been found to have cardioprotective properties and may help to reduce the risk of heart disease. It has been studied as a potential treatment for high blood pressure, atherosclerosis, and varicose veins.
Cognitive function. Rutin has been found to have potential cognitive-enhancing properties and may help to improve memory and learning ability. It has been studied as a potential treatment for age-related cognitive decline and Alzheimer’s disease.
Anticancer. Rutin has been found to have potential anticancer properties, which can help to inhibit the growth and spread of cancer cells. It has been studied as a potential treatment for various types of cancer, including breast, colon, and prostate cancer.
Side-effects
Rutin has limited bioavailability, meaning that the body may not absorb it well. This can make it difficult to achieve therapeutic levels of rutin through dietary sources alone.
Some people may experience side effects from rutin supplements, including digestive upset, headaches, and allergic reactions. It is important to talk to your healthcare provider before using rutin if you have any health conditions or are taking any medications.
Rutin may interact with some medications, including blood thinners and medications for anxiety and depression. If you are taking any medications, it is important to talk to your healthcare provider before using rutin.
Rutin supplements are not recommended for use during pregnancy or breastfeeding due to a lack of safety data.
10. Curcumin
Curcumin is a natural compound found in the spice turmeric. It has been studied extensively for its potential health benefits, including its anti-inflammatory and antioxidant properties.
Curcumin has several potential health benefits, including its anti-inflammatory and antioxidant properties, potential pain relief, cognitive benefits, and potential cancer-fighting properties.
Turmeric root contains small amounts of curcumin
Benefits
Anti-inflammatory. Curcumin has been found to have potent anti-inflammatory properties, which can help to reduce inflammation throughout the body. Chronic inflammation is a contributing factor in many chronic diseases, including heart disease, diabetes, and cancer.
Antioxidant. Curcumin has also been found to have antioxidant properties, which can help to protect the body against damage from free radicals. Free radicals can contribute to the development of chronic diseases such as cancer and Alzheimer’s disease.
Pain-relief. Curcumin has been found to have potential pain-relieving properties, which can help to reduce pain and discomfort in people with conditions such as osteoarthritis.
Cognition. Curcumin has been found to have potential cognitive benefits, including the ability to improve memory and reduce the risk of age-related cognitive decline.
Anticancer. Curcumin has been found to have potential anticancer properties and may be able to inhibit the growth of cancer cells.
Side-effects
Curcumin has low bioavailability, meaning that the body may not absorb it well. This can make it difficult to achieve therapeutic levels of curcumin through dietary sources alone. (Pepper contains substances that improve the absorption.)
Some people may experience side effects from curcumin supplements, including digestive upset, headaches, and allergic reactions. It is important to talk to your healthcare provider before using curcumin if you have any health conditions or are taking any medications.
Curcumin may interact with some medications, including blood thinners and medications for diabetes. If you are taking any medications, it is important to talk to your healthcare provider before using curcumin.
Curcumin supplements are not recommended for use during pregnancy or breastfeeding due to a lack of safety data.
11. Berberine
Berberine is a natural compound found in several plants such as Berberis vulgaris, Berberis aristata, and Coptis chinensis. Berberine has been used in traditional Chinese and Ayurvedic medicine for thousands of years for its medicinal properties. In recent years, it has gained attention in the Western world for its potential health benefits, such as regulating blood sugar and cholesterol levels, reducing inflammation, and aiding in weight loss.
Benefits
Blood sugar. Berberine has been found to be effective in reducing blood sugar levels in people with type 2 diabetes. It works by activating an enzyme called AMPK, which helps regulate glucose uptake in the body. Studies have shown that berberine can reduce fasting blood sugar levels, HbA1c levels, and improve insulin sensitivity.
Cholesterol levels. High cholesterol levels are a risk factor for heart disease. Berberine has been found to reduce LDL cholesterol and triglyceride levels, while increasing HDL cholesterol levels. This makes it a promising natural alternative to statin drugs.
Anti-inflammatory. Berberine has been shown to have anti-inflammatory properties, which may be beneficial in treating a variety of conditions such as arthritis, Alzheimer’s disease, and cancer. It works by reducing the production of inflammatory cytokines, which can lead to chronic inflammation.
Antimicrobial. Berberine has antimicrobial properties, making it effective in treating various infections caused by bacteria, viruses, and fungi. It has been found to be effective in treating diarrhea caused by E. coli, cholera, and other bacterial infections. It has also been shown to be effective in treating fungal infections such as candida.
Weight loss. Berberine has been found to aid in weight loss by increasing metabolism, reducing fat storage, and decreasing insulin resistance. It has also been shown to reduce appetite and food intake.
Side-effects
Berberine can cause side effects in some people, such as nausea, diarrhea, stomach pain, and constipation. It can also cause low blood pressure and heart palpitations in people with pre-existing heart conditions.
Berberine can interact with certain medications, such as blood thinners, statins, and antidepressants. It can also increase the effects of drugs that lower blood sugar levels, such as metformin.
There is limited research on the safety of berberine during pregnancy and breastfeeding. Therefore, it is not recommended for use during these periods.
Despite its potential health benefits, the research on berberine is still limited. Most studies have been done on animals or small human populations, making it difficult to draw definitive conclusions about its effectiveness.
12. Metformin
Metformin is a prescription medication that is commonly used to treat type 2 diabetes. It is also being studied for its potential to treat other conditions, such as polycystic ovary syndrome (PCOS), obesity, and cancer. In this article, we will discuss the benefits and drawbacks of using metformin.
Overall, metformin is an effective medication for treating type 2 diabetes and has shown promise in treating other conditions, such as PCOS, obesity, and cancer. However, it can cause gastrointestinal side effects, vitamin B12 deficiency, lactic acidosis, and kidney problems. It can also interact with other medications, so it is important to talk to your doctor before taking metformin. If you are considering taking metformin, your doctor can help you weigh the potential.
Benefits
Blood sugar. Metformin is used to lower blood sugar levels in people with type 2 diabetes. It works by reducing the amount of glucose produced by the liver and improving the body’s ability to use insulin. This can help to prevent complications of diabetes, such as nerve damage, kidney damage, and eye problems.
Weight loss. Metformin has been shown to help people lose weight, especially in those with type 2 diabetes who are overweight or obese. It works by reducing appetite, increasing satiety, and reducing the absorption of calories from food. Studies have shown that metformin can lead to a modest reduction in body weight, which can have significant health benefits.
PCOS treatment. Metformin is also used to treat PCOS, a condition that affects women’s hormone levels, leading to irregular periods, acne, and excess hair growth. Metformin helps to regulate the levels of insulin in the body, which can improve symptoms of PCOS, such as irregular periods and fertility problems.
Cardiovascular health. Metformin has been shown to improve cardiovascular health by reducing the risk of heart attacks and strokes in people with type 2 diabetes. It also helps to reduce inflammation, which can be a risk factor for cardiovascular disease.
Anticancer. There is evidence to suggest that metformin may help to prevent certain types of cancer. It works by reducing the levels of insulin and glucose in the body, which can inhibit the growth of cancer cells. Some studies have shown that metformin may reduce the risk of breast, colon, and prostate cancer.
Side-effects
Metformin can cause gastrointestinal side effects, such as nausea, vomiting, diarrhea, and abdominal discomfort. These side effects usually go away on their own, but some people may need to switch to a different medication.
Metformin can cause a deficiency in vitamin B12, which can lead to anemia, nerve damage, and other health problems. It is important for people taking metformin to have their vitamin B12 levels checked regularly and to take supplements if necessary.
In rare cases, metformin can cause a serious condition called lactic acidosis, which is a buildup of lactic acid in the blood. This can be life-threatening and requires immediate medical attention. Symptoms of lactic acidosis include weakness, muscle pain, and difficulty breathing.
Metformin can cause kidney problems in people with pre-existing kidney disease or other conditions that can affect kidney function. It is important for people taking metformin to have their kidney function checked regularly.
Metformin can interact with other medications, such as certain antibiotics and blood pressure medications. It is important to talk to your doctor before taking metformin if you are taking any other medications.
13. Lutein and Zeaxanthin
Lutein and zeaxanthin are two carotenoids that are found in many fruits and vegetables, such as kale, spinach, and broccoli. These compounds are also available as dietary supplements, and they are often promoted for their potential health benefits, such as protecting eye health, reducing inflammation, improving skin health, and supporting cognitive and heart health.
Benefits
Eye health. The carotenoids are known for their ability to protect eye health. They are both found in the macula, the central part of the retina that is responsible for our central vision. These compounds act as a natural filter, protecting the macula from harmful blue light and oxidative stress. Studies have shown that supplementation with these can improve visual function and reduce the risk of age-related macular degeneration and cataracts.
Anti-inflammatory. Lutein and zeaxanthin have been found to have anti-inflammatory properties, which can help reduce chronic inflammation in the body. Chronic inflammation is linked to many health problems, including heart disease, cancer, and arthritis. By reducing inflammation, it may help reduce the risk of these conditions.
Skin health. The carotenoids may also be beneficial for skin health. They act as antioxidants, protecting the skin from oxidative damage caused by exposure to the sun and other environmental factors. Studies have shown that their supplementation can improve skin hydration, elasticity, and overall appearance.
Cognitive function. Lutein and zeaxanthin may also have a positive impact on cognitive function. They are found in high concentrations in the brain and have been found to improve memory and processing speed in older adults. They may also have a protective effect against age-related cognitive decline.
Heart health. The carotenoids have been found to have a positive impact on heart health. They act as antioxidants, reducing oxidative stress in the body, and they may also help improve blood lipid profiles. Studies have shown that lutein and zeaxanthin supplementation can reduce blood pressure and improve blood flow, which can reduce the risk of heart disease.
Side-effects
Lutein and zeaxanthin are generally considered safe when consumed in the recommended doses. However, they can cause side effects in some people, such as digestive problems, headache, and allergic reactions.
The carotenoids can interact with certain medications, such as blood thinners and cholesterol-lowering drugs. Therefore, it is important to consult with a healthcare provider before taking these supplements.
Despite their potential health benefits, the research on lutein and zeaxanthin is still limited. Most studies have been done on small human populations or animals, making it difficult to draw definitive conclusions about their effectiveness.
While the carotenoids supplements may provide some health benefits, they are not a substitute for a healthy diet. Eating a diet rich in fruits and vegetables is the best way to obtain these compounds, along with other important nutrients and antioxidants.
14. Astaxanthin
Astaxanthin is a natural pigment that belongs to the carotenoid family. It is found in several types of seafood, such as salmon, shrimp, and lobster, as well as some microalgae. Astaxanthin supplements are also available and have been promoted for their potential health benefits, such as antioxidant properties, improving eye and skin health, enhancing exercise performance, and supporting cardiovascular health.
Astaxanthin from Organic Microalgae
Benefits
Antioxidant. Astaxanthin is a powerful antioxidant, which means that it can protect the body from oxidative stress caused by free radicals. This oxidative stress can lead to inflammation and damage to cells, tissues, and organs, which can increase the risk of chronic diseases such as cancer, heart disease, and Alzheimer’s. By reducing oxidative stress, astaxanthin may help prevent or slow the progression of these diseases.
Eye health. Astaxanthin has been found to have a positive impact on eye health. It can cross the blood-brain barrier and reach the retina, where it can protect the eyes from oxidative stress and inflammation. Studies have shown that astaxanthin supplementation can improve visual function, reduce eye fatigue, and reduce the risk of age-related macular degeneration.
Skin health. Astaxanthin may also be beneficial for skin health. It acts as an antioxidant, protecting the skin from UV damage and other environmental factors. Studies have shown that astaxanthin supplementation can improve skin hydration, reduce the appearance of fine lines and wrinkles, and improve skin elasticity.
Exercise performance. Astaxanthin may also have a positive impact on exercise performance. It has been found to reduce muscle damage and inflammation caused by intense exercise, as well as improve endurance and strength. Astaxanthin supplementation may be particularly beneficial for athletes and people who engage in high-intensity exercise.
Cardiovascular system. Astaxanthin has been found to have a positive impact on cardiovascular health. It can improve blood lipid profiles, reduce inflammation, and improve blood flow. Studies have shown that astaxanthin supplementation can reduce blood pressure, improve arterial stiffness, and reduce the risk of heart disease.
Side-effects
Astaxanthin is generally considered safe when consumed in the recommended doses. However, it can cause side effects in some people, such as digestive problems, headache, and allergic reactions.
Astaxanthin supplements can interact with certain medications, such as blood thinners and cholesterol-lowering drugs. Therefore, it is important to consult with a healthcare provider before taking these supplements.
The quality of astaxanthin supplements can vary greatly. Some supplements may contain contaminants or may not contain the labeled amount of astaxanthin. Therefore, it is important to choose a reputable brand and purchase from a trusted source.
Despite its potential health benefits, the research on astaxanthin is still limited. Most studies have been done on small human populations or animals, making it difficult to draw definitive conclusions about its effectiveness.
Astaxanthin supplements can be more expensive than other types of supplements. This may make them less accessible to some people.
15. Anthocyanins
Anthocyanins are water-soluble pigments that are naturally occurring in plants, particularly in fruits, berries, and vegetables. They belong to a group of flavonoids, which are antioxidants known for their potential health benefits, such as being anticancer, anti-inflammatory, anti-diabetes, and neurological diseases. Anthocyanins are responsible for the red, blue, and purple colors in fruits and vegetables, and are often used as natural food colorants.
Anthocyanins are powerful antioxidants with a range of potential health benefits, including anti-inflammatory properties, brain health benefits, and cancer-fighting properties. While they do have some potential drawbacks, such as low bioavailability and interactions with medications, they are generally safe for most people to consume.
There are several different types of anthocyanins, including:
- Cyanidin is a reddish-purple dye found in blueberry, blackcurrant, cherries, grape skins, lingonberry, and red onion skins.
- Delphinidin is purple or blue in color abundant in cranberries, blueberries, blackcurrants, and pomegranates.
- Europinidin is bluish-red, water-soluble dye found in certain flowers Plumbago and Ceratostigma.
- Malvidin is a blue colored dye that is found in the blue pimpernel, red wine, and saskatoon berries.
- Pelargonidin is an orange color used in food and industrial dyes red geranium flowers, ripe raspberries, strawberries, blueberries, blackberries, and cranberries.
- Peonidin is a purplish-red dye that gives hues to flowers peony and roses.
- Petunidin is a dark-red or purple colored pigment found in many red berries aronia, Saskatoon berries, and grapes.
- Quercetin is a yellow pigment found in apples, green tea, berries, grape skin, and onion skin.
If you are interested in incorporating more anthocyanins into your diet, consider adding more fruits and vegetables with red, blue, and purple colors, such as maqui berries, blueberry juice, cranberry juice, acai berry juice, schisandra berry, noni fruit, acerola cherry, sea buckthorn juice, camu camu fruit, goji berry juice, pitaya juice / dragon fruit juice, pomegranate juice, lingonberry, raspberries, blackberries, red grapes, black Beluga lenses, red onions, and purple sweet potatoes.
Benefits
Antioxidant. Anthocyanins are powerful antioxidants that scavenge free radicals in the body. They help protect the body against oxidative stress, which has been linked to a number of chronic diseases such as cancer, diabetes, and heart disease.
Anti-Inflammatory. Anthocyanins have anti-inflammatory properties that can help reduce inflammation in the body. Chronic inflammation is also linked to many chronic diseases, so reducing inflammation is important for overall health.
Brain health. There is evidence to suggest that anthocyanins may have benefits for brain health. Studies have shown that they can help improve cognitive function, memory, and learning ability. This is thought to be due to their ability to reduce oxidative stress and inflammation in the brain.
Eye function. Anthocyanins may also benefit eye health. They can help improve blood flow to the eyes and reduce inflammation, which can help prevent age-related eye diseases such as macular degeneration and cataracts.
Heart health. There is some evidence to suggest that anthocyanins can help improve heart health. They can help reduce blood pressure, improve blood flow, and reduce inflammation, all of which are important for heart health.
Anticancer. Anthocyanins have been shown to have potential cancer-fighting properties. They can help reduce the growth of cancer cells and induce apoptosis (cell death) in cancer cells. While more research is needed in this area, this is promising for cancer prevention and treatment.
Side-effects
One of the main drawbacks of anthocyanins is that they are not very bioavailable. This means that they are not easily absorbed by the body, and therefore may not have the same benefits as other antioxidants. However, there are ways to increase the bioavailability of anthocyanins, such as consuming them with other foods that contain fat or with black pepper.
While rare, some people may be allergic to anthocyanins. Symptoms of an allergic reaction can include hives, swelling, and difficulty breathing.
Anthocyanins may interact with some medications, particularly blood thinners. If you are taking any medications, it is important to speak with your healthcare provider before consuming anthocyanins.
While rare, some people may experience side effects from consuming anthocyanins. These can include gastrointestinal issues such as stomach cramps, diarrhea, and nausea.
While anthocyanins have been studied extensively, there is still much we do not know about their long-term effects. More research is needed in this area to fully understand the potential benefits and drawbacks of anthocyanin consumption.
16. Oligomeric Proanthocyanidins (OPC)
Oligomeric proanthocyanidins (OPCs) are naturally occurring plant compounds found in some vegetables and plants, but in particular in grape seeds and pine bark. They belong to a class of flavonoids, which are known for their antioxidant properties. OPCs have gained popularity as a dietary supplement due to their potential health benefits, ranging from improving cardiovascular health, easing swelling in the joints, supporting the immune system, promoting healthy skin, and to reducing inflammation.
Benefits
Antioxidant. OPCs are potent antioxidants that help protect cells from free radical damage. Free radicals are unstable molecules that can damage cells, leading to inflammation and chronic diseases.
Cardiovascular system. OPCs have been shown to improve cardiovascular health by reducing inflammation, improving blood flow, and lowering blood pressure. OPCs have been found to increase the production of nitric oxide, a molecule that helps relax blood vessels and improve blood flow.
Skin health. OPCs are known for their ability to promote healthy skin. They help protect the skin from UV damage and reduce the signs of aging. OPCs have been shown to improve skin elasticity, reduce the appearance of wrinkles, and protect the skin from sun damage.
Immune system. OPCs have been found to support the immune system by reducing inflammation and oxidative stress. They help protect immune cells from damage and promote their proper function.
Anti-Inflammatory. OPCs have been found to have anti-inflammatory properties, which can help reduce inflammation throughout the body. This can help reduce the risk of chronic diseases, such as heart disease, cancer, and arthritis.
Side-effects
OPCs are generally considered safe, but some people may experience side effects such as headaches, dizziness, and upset stomach.
OPCs may interact with certain medications, including blood thinners, blood pressure medications, and chemotherapy drugs. It is important to consult with a healthcare provider before taking OPC supplements if you are on any medications.
OPC supplements are not standardized, meaning the amount of OPCs in a supplement can vary widely. This can make it difficult to determine the appropriate dosage.
While there is some evidence to suggest that OPCs have health benefits, much of the research has been conducted in animal models or in vitro studies. More human studies are needed to confirm the potential health benefits of OPCs.
OPC supplements can be expensive, particularly if they are derived from high-quality sources such as grape seed extract. This can make it difficult for some people to afford regular supplementation.
17. EGCG (Epigallocatechin Gallate)
Epigallocatechin gallate (EGCG) is a type of catechin, a class of natural flavonoids found in various plants, but most abundant in green tea. EGCG is a powerful antioxidant and has been the subject of numerous studies investigating its potential health benefits.
EGCG has many potential health benefits and is considered safe when consumed in moderation.
Benefits
Antioxidant. EGCG has strong antioxidant properties and can protect the body from oxidative stress, which is linked to numerous health conditions, including cancer, heart disease, and cognitive decline. EGCG’s antioxidant activity may also help reduce inflammation in the body and prevent cellular damage.
Weight loss. EGCG has been studied for its potential to aid in weight loss. Studies have suggested that EGCG may help boost metabolism and increase fat oxidation, which may contribute to weight loss. EGCG may also help reduce appetite and increase satiety, leading to lower caloric intake.
Cardiovascular system. EGCG has been found to have cardioprotective effects, including improving blood lipid profiles by lowering total cholesterol, triglycerides, and LDL cholesterol. EGCG has also been shown to reduce blood pressure and improve endothelial function, which is important for healthy blood flow.
Anticancer. EGCG has been studied for its potential to prevent and treat cancer. It may help inhibit the growth of cancer cells and cause apoptosis (cell death) in cancer cells. EGCG has been shown to have promising results in studies on breast, prostate, colon, and lung cancers.
Cognitive function. EGCG has been found to have neuroprotective effects, which may contribute to improved cognitive function and a reduced risk of age-related cognitive decline. EGCG has been studied for its potential to help prevent neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
Side-effects
While EGCG has many potential health benefits, its bioavailability is limited. EGCG is poorly absorbed by the body, and much of it is excreted. This means that consuming large amounts of EGCG may not necessarily result in increased levels in the body.
EGCG has been found to interact with certain medications, including blood thinners and chemotherapy drugs. It is important to consult with a healthcare provider before taking EGCG if you are taking any medications.
EGCG is most abundant in green tea, which also contains caffeine. While moderate caffeine intake is generally safe for most people, high levels of caffeine intake can cause negative side effects such as anxiety, insomnia, and increased heart rate.
There have been rare reports of liver toxicity associated with EGCG consumption, particularly in high doses. However, more research is needed to fully understand the potential risks.
18. Luteolin
Luteolin is a rare flavonoid that belongs to a group of natural compounds that are known for their antioxidant, anti-inflammatory, and anticancer properties. It is found in various plants, including celery, peppers, carrots, and chamomile tea, but only in minimal amounts. Overall, luteolin is a promising compound with many potential health benefits, including antioxidant, anti-inflammatory, and anticancer properties.
However, the amount of luteolin in food sources may not be enough to provide the desired health benefits. In these cases, supplements may be necessary to achieve the desired effects.
Benefits
Anti-inflammatory antioxidant. One of the key benefits of luteolin is its antioxidant properties. It can neutralize free radicals in the body, which are unstable molecules that can damage cells and contribute to aging, chronic diseases, and cancer. In addition, luteolin has been shown to have anti-inflammatory effects by inhibiting the production of pro-inflammatory molecules in the body. This makes it a potential treatment for conditions such as arthritis, asthma, and inflammatory bowel disease.
Anticancer. Luteolin has also been found to have potential anticancer properties. It has been shown to inhibit the growth and spread of cancer cells in the body, including breast, lung, colon, and prostate cancer. This is thought to be due to its ability to induce apoptosis (cell death) in cancer cells and prevent their growth.
Neuroprotective. In addition, luteolin may have neuroprotective effects. Studies have suggested that it may help protect the brain from damage and reduce the risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. It has also been found to have potential benefits for cardiovascular health, such as reducing inflammation in the blood vessels and improving blood flow.
Side-effects
While there are many potential benefits to using luteolin, there are also some drawbacks to consider. One potential issue is that it may interact with certain medications, such as blood thinners, and increase the risk of bleeding.
In addition, some individuals may experience allergic reactions to luteolin. This can result in symptoms such as hives, itching, and difficulty breathing. If you experience any of these symptoms, stop using luteolin and seek medical attention immediately.
There is also limited information on the long-term safety of luteolin supplementation. While short-term use is generally considered safe, more research is needed to determine the safety and effectiveness of long-term use.
19. Allicin
Allicin is a compound found in garlic that has been studied for its potential health benefits, including antimicrobial, cardiovascular, and immune system support, as well as antioxidant, anti-inflammatory, and potentially anticancer properties.
Benefits
Antimicrobial. One of the primary benefits of allicin is its antimicrobial properties. It has been shown to be effective against a variety of bacteria, viruses, and fungi, including E. coli, Staphylococcus aureus, and Candida albicans. This makes it a potentially useful treatment for a variety of infections.
Cardiovascular system. Allicin has been found to have a beneficial effect on cardiovascular health. It has been shown to lower blood pressure, reduce cholesterol levels, and improve circulation. This makes it a potentially useful supplement for people with high blood pressure or high cholesterol.
Antioxidant. Allicin is also a potent antioxidant, meaning that it helps to protect the body from the damaging effects of free radicals. This can help to reduce the risk of chronic diseases such as cancer, Alzheimer’s disease, and Parkinson’s disease.
Anti-inflammatory. In addition to its antimicrobial and antioxidant properties, allicin also has anti-inflammatory properties. This makes it a potentially useful supplement for people with chronic inflammatory conditions such as rheumatoid arthritis.
Immune System. Allicin has been found to stimulate the immune system, which may help to improve the body’s ability to fight off infections.
Anticancer. Some studies have suggested that allicin may have anticancer properties. It has been found to induce cell death in cancer cells and may help to prevent the growth and spread of tumors.
Side-effects
One of the most well-known drawbacks of using allicin is the odor that it produces. This is due to the sulfur compounds in garlic, which are released when the garlic is crushed or chopped. This odor can be difficult to mask and may be unpleasant for some people.
Some people may experience gastrointestinal issues such as bloating, gas, and diarrhea when taking allicin supplements. These side effects are generally mild and can be reduced by taking the supplement with food.
Allicin may interact with certain medications, including blood thinners and medications used to treat HIV. People taking these medications should consult with their doctor before taking allicin supplements.
Some people may be allergic to allicin or other components of garlic. Symptoms of an allergic reaction may include hives, itching, and difficulty breathing.
While there is some evidence to suggest that allicin has potential health benefits, much of the research in this area has been conducted in laboratory settings or with animal models. More research is needed to confirm the potential benefits of allicin in humans.
20. Lycopene
Lycopene is a natural pigment found in many fruits and vegetables, including tomatoes, watermelons, papayas, and guavas. It is known for its antioxidant properties and is often used as a dietary supplement. It may help reduce the risk of chronic diseases such as heart disease and cancer, and improve skin health. However, there are also potential drawbacks to taking lycopene supplements, including side effects, limited absorption, interactions with other nutrients, and a lack of standardization.
Benefits
Antioxidant. Lycopene is a powerful antioxidant that helps protect cells from damage caused by free radicals. This can help reduce the risk of chronic diseases such as heart disease, cancer, and Alzheimer’s disease.
Anticancer. Some studies have suggested that lycopene may help reduce the risk of prostate cancer. This may be due to its ability to block the growth of cancer cells and reduce inflammation.
Skin health. Lycopene may also help improve skin health by reducing damage caused by UV rays and increasing collagen production. This can help reduce the appearance of wrinkles and other signs of aging.
Cardiovascular system. Lycopene has been shown to help reduce the risk of heart disease by lowering cholesterol levels and improving blood vessel function. It may also help reduce inflammation, which is a major contributor to heart disease.
Side-effects
Like any supplement, lycopene can cause side effects in some people and common side effects include stomach upset, diarrhea, and allergic reactions. It may also interact with certain medications, so it is important to talk to your healthcare provider before taking a lycopene supplement.
Lycopene is not easily absorbed by the body, which can limit its effectiveness. However, it is more easily absorbed when consumed with a source of fat, such as olive oil or avocado.
Lycopene may interact with other nutrients in the body, such as vitamin E and selenium. This can lead to an imbalance in the body and potentially cause health problems.
Lycopene supplements are not standardized, which means that the amount of lycopene in each supplement can vary. If you are considering taking a lycopene supplement, it is important to talk to your healthcare provider to determine if it is safe and appropriate for you.
21. L-Glutathione (GSH)
Reduced L-Glutathione (GSH) is a naturally occurring antioxidant produced by the body that has been the focus of research in recent years for its potential health benefits. There are two key forms of glutathione: Reduced L-glutathione (GSH) and oxidized glutathione (GSSG) are two forms of glutathione that exist in the body, and they have different properties and functions.
L-glutathione (GSH) is the active, reduced form of glutathione that functions as an antioxidant in the body. It helps to protect cells from damage caused by free radicals and reactive oxygen species (ROS). GSH is produced by the body and is found in high concentrations in the liver, lungs, and other organs.
GSH acts as a reducing agent, which means that it can donate electrons to other molecules, helping to neutralize free radicals and prevent oxidative damage. GSH is also important for the detoxification of harmful substances, such as drugs and environmental toxins. It helps to bind to these substances and remove them from the body.
Benefits
Antioxidant. Glutathione is a powerful antioxidant that helps to neutralize free radicals and reduce oxidative stress in the body. This is important because oxidative stress can damage cells and contribute to a wide range of diseases, including cancer, Alzheimer’s disease, and Parkinson’s disease.
Immune system. Glutathione plays an important role in supporting the immune system by helping to neutralize harmful toxins and pathogens in the body. Studies have shown that low levels of glutathione are associated with increased susceptibility to infections and other immune-related disorders.
Protection against toxins. Glutathione is also important for protecting the body against environmental toxins, such as air pollution, heavy metals, and pesticides. This is because glutathione helps to bind to these toxins and remove them from the body.
Liver function. The liver is responsible for detoxifying the body, and glutathione plays a key role in this process. Studies have shown that glutathione supplementation can help to support liver function and reduce the risk of liver damage and disease.
Skin health. Glutathione is also being studied for its potential benefits for skin health. Some studies have shown that glutathione can help to reduce the appearance of age spots, improve skin texture, and even out skin tone.
Side-effects
While glutathione is generally considered safe, some individuals may experience side effects, such as gastrointestinal upset or allergic reactions.
Glutathione is not well absorbed when taken orally, meaning that it may not be as effective as a supplement. Some supplements claim to increase glutathione levels by providing precursors, such as cysteine, but the effectiveness of these supplements is still unclear. However, reduced L-glutathione (GSH) is the active, reduced form of glutathione, which is better absorbed in the body.
Because glutathione helps to neutralize toxins and free radicals, it may mask symptoms of underlying health conditions, making it difficult to diagnose and treat these conditions.
Glutathione supplements may interfere with the effectiveness of chemotherapy in cancer patients, and should not be taken without the advice of a healthcare professional.
Glutathione supplements can be expensive, which may make them inaccessible to some individuals.
If you are considering taking glutathione as a supplement, it is important to talk to your healthcare provider first. They can help you determine whether glutathione is right for you and recommend an appropriate dosage.
22. Cycloastragenol (CAG)
Cycloastragenol is a natural compound derived from the root of the astragalus plant, which has been traditionally used in traditional Chinese medicine for its potential health benefits. In recent years, cycloastragenol has gained attention for its potential anti-aging effects and other health benefits, but while it shows promise as a potential anti-aging and health-promoting supplement, there is limited clinical evidence to support its use in humans.
Benefits
Anti-aging. Cycloastragenol has been shown to activate telomerase, an enzyme that maintains and lengthens telomeres. Telomeres are the protective caps at the end of DNA strands that shorten as we age, leading to cellular damage and aging. By activating telomerase, cycloastragenol may slow down the aging process.
Immune system. Studies have shown that cycloastragenol may enhance the function of immune cells, including natural killer cells, which play a critical role in defending against infections and cancer.
Cardiovascular system. Cycloastragenol has been shown to improve cardiovascular health by reducing inflammation, promoting the growth of new blood vessels, and lowering blood pressure.
Neuroprotective. Studies have suggested that cycloastragenol may have neuroprotective effects, potentially reducing the risk of cognitive decline and neurological disorders.
Skin health. Cycloastragenol has been shown to improve the health and appearance of skin by reducing inflammation, protecting against oxidative damage, and promoting collagen synthesis.
Side-effects
Cycloastragenol may cause side effects, including gastrointestinal upset, headaches, and allergic reactions. Long-term use may also increase the risk of cancer, although this has not been definitively established.
Cycloastragenol may interact with certain medications, including blood thinners, immunosuppressants, and diabetes medications. Individuals taking these medications should consult with a healthcare provider before taking cycloastragenol.
It is important to ensure that cycloastragenol supplements are obtained from sustainable sources.
While there have been several preclinical studies on the potential health benefits of cycloastragenol, there is currently limited clinical evidence to support its use in humans.
23. Sulforaphane
Sulforaphane is a natural compound found in cruciferous vegetables such as broccoli, cauliflower, and kale. It is known for its potent antioxidant and anti-inflammatory properties and has been studied extensively for its potential health benefits, such as antioxidant and anti-inflammatory properties, cancer prevention, and supporting brain and cardiovascular health.
Broccoli sprouts contains small amounts sulforaphane (glucobrassicin)
Benefits
Antioxidant. Sulforaphane is a potent antioxidant that can protect cells from oxidative damage caused by free radicals. This oxidative damage can lead to inflammation and increase the risk of chronic diseases such as cancer, heart disease, and Alzheimer’s. By reducing oxidative stress, sulforaphane may help prevent or slow the progression of these diseases.
Anti-inflammatory. Sulforaphane also has anti-inflammatory properties, which means it can reduce inflammation in the body. Chronic inflammation is a key contributor to many chronic diseases and conditions such as arthritis, heart disease, and diabetes. By reducing inflammation, sulforaphane may help prevent or manage these conditions.
Anticancer. Sulforaphane has been extensively studied for its potential cancer-fighting properties. It has been found to inhibit the growth and spread of cancer cells, as well as induce apoptosis (programmed cell death) in cancer cells. Studies have shown that sulforaphane may be effective in preventing or slowing the progression of several types of cancer, including breast, prostate, and colon cancer.
Brain function. Sulforaphane has also been found to have positive effects on brain health. It can cross the blood-brain barrier and reach the brain, where it can protect brain cells from oxidative stress and inflammation. Studies have shown that sulforaphane may improve cognitive function and memory, as well as reduce the risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
Cardiovascular system. Sulforaphane has been found to have a positive impact on cardiovascular health. It can lower blood pressure, reduce inflammation, and improve blood vessel function. Studies have shown that sulforaphane supplementation may reduce the risk of heart disease and stroke.
Side-effects
While sulforaphane has many potential health benefits, its bioavailability is limited. This means that the body may not be able to absorb and use it effectively. To increase the bioavailability of sulforaphane, it is often consumed in the form of supplements or extracts.
Sulforaphane supplements can interact with certain medications, such as blood thinners and chemotherapy drugs. Therefore, it is important to consult with a healthcare provider before taking these supplements.
Sulforaphane supplements are generally considered safe when consumed in the recommended doses. However, they can cause side effects in some people, such as digestive problems, headache, and allergic reactions.
While there is promising research on the potential health benefits of sulforaphane, the research is still limited. Most studies have been done on small human populations or animals, making it difficult to draw definitive conclusions about its effectiveness.
24. Indole-3-Carbinol (I3C)
Indole-3-carbinol (I3C) is a natural compound found in cruciferous vegetables such as broccoli, cabbage, and kale. It has been studied extensively for its potential health benefits and is often taken as a dietary supplement. In this article, we will explore the benefits and drawbacks of using I3C.
Benefits
Anticancer. I3C has been extensively studied for its potential cancer-fighting properties. It has been found to induce apoptosis (programmed cell death) in cancer cells and inhibit the growth and spread of several types of cancer, including breast, prostate, and colon cancer. I3C works by increasing the activity of certain enzymes that help the body eliminate carcinogens and reducing the production of cancer-promoting enzymes.
Hormonal balance. I3C has been found to help balance hormones in the body, particularly estrogen. It works by converting estrogen into less potent forms, which can help reduce the risk of estrogen-related cancers such as breast cancer. I3C may also help improve symptoms of premenstrual syndrome (PMS) and menopause.
Anti-inflammatory. I3C also has anti-inflammatory properties, which means it can reduce inflammation in the body. Chronic inflammation is a key contributor to many chronic diseases and conditions such as arthritis, heart disease, and diabetes. By reducing inflammation, I3C may help prevent or manage these conditions.
Digestion. I3C has been found to have positive effects on digestive health. It can help reduce the risk of digestive disorders such as inflammatory bowel disease (IBD) and colon cancer. I3C may also help improve symptoms of conditions such as acid reflux and indigestion.
Skin health. I3C has been found to have positive effects on skin health. It can help reduce the production of sebum, which can lead to acne, and may help improve the appearance of fine lines and wrinkles. I3C may also help protect the skin from UV damage and reduce the risk of skin cancer.
Side-effects
Like many natural compounds, the bioavailability of I3C is limited, which means the body may not be able to absorb and use it effectively. To increase the bioavailability of I3C, it is often consumed in the form of supplements or extracts.
It can interact with certain medications, such as blood thinners and chemotherapy drugs. Therefore, it is important to consult with a healthcare provider before taking these supplements.
It is generally considered safe when consumed in the recommended doses. However, they can cause side effects in some people, such as digestive problems, headache, and allergic reactions.
While there is promising research on the potential health benefits of I3C, the research is still limited. Most studies have been done on small human populations or animals, making it difficult to draw definitive conclusions about its effectiveness.
25. AHCC (Active Hexose Correlated Compound
Active Hexose Correlated Compound (AHCC) is a natural supplement derived from the mycelia of shiitake mushrooms. It has been used in traditional Japanese medicine for its immune-boosting properties and is now gaining popularity in Western medicine. In this article, we will discuss the benefits and drawbacks of using AHCC.
Benefits
Immune system. AHCC has been shown to enhance the immune system by increasing the activity of natural killer (NK) cells, T-cells, and macrophages. These immune cells play a crucial role in defending the body against foreign invaders such as viruses and cancer cells. AHCC also helps to boost the production of cytokines, which are signaling molecules that coordinate the immune response.
Anticancer. AHCC has been studied for its potential anticancer properties. In a laboratory study, AHCC was found to inhibit the growth of human prostate cancer cells. It has also been shown to enhance the effectiveness of chemotherapy in cancer patients. In a study of patients with liver cancer, those who took AHCC had a higher rate of survival than those who did not.
Liver health. AHCC has been shown to have protective effects on the liver. In a study of patients with chronic hepatitis C, those who took AHCC had a significant improvement in liver function tests. AHCC has also been studied for its potential to prevent liver damage caused by alcohol and other toxins.
Digestion. AHCC has been shown to improve digestive health by reducing inflammation in the gut. In a study of patients with ulcerative colitis, those who took AHCC had a significant reduction in symptoms compared to those who did not.
Stress-relief. AHCC has been studied for its potential to reduce stress and anxiety. In a study of healthy adults, those who took AHCC had a reduction in stress markers compared to those who did not.
Side-effects
AHCC is generally considered safe, but some people may experience side effects such as nausea, diarrhea, and fatigue. These side effects are usually mild and go away on their own.
It may interact with certain medications, such as those used to treat cancer and autoimmune diseases. It is important to talk to your doctor before taking AHCC if you are taking any medications.
As it is derived from shiitake mushrooms, and some people may be allergic to it. If you have a mushroom allergy, you should avoid taking AHCC.
The product can be expensive, especially if you are taking it on a regular basis. It is important to weigh the potential benefits against the cost.
While there is some evidence to support the benefits of AHCC, the research is still limited. Most studies have been small and conducted on animals or in vitro. More research is needed to confirm the effectiveness of AHCC in humans.
26. Milk thistle (Silymarin)
Milk thistle (Silybum marianum) is a flowering herb that is native to the Mediterranean region and has been used for centuries as a natural remedy for liver and gallbladder problems. The extract of milk thistle, known as silymarin, is a mixture of several active compounds, including silibinin, silydianin, and silychristin. Silymarin is the primary active ingredient responsible for the potential health benefits such as liver health, being an antioxidant, anti-inflammatory properties, skin health, and blood sugar control.
Benefits
Liver health. Silymarin has been shown to have hepatoprotective effects, which means it helps protect the liver from damage caused by toxins, drugs, and other environmental factors. Several studies have demonstrated that silymarin can improve liver function tests in individuals with liver diseases such as hepatitis, cirrhosis, and non-alcoholic fatty liver disease.
Antioxidant. Silymarin has potent antioxidant properties that can help protect the body from the damaging effects of free radicals. Free radicals are unstable molecules that can cause cellular damage and are associated with the development of chronic diseases such as cancer, heart disease, and Alzheimer’s disease.
Anti-inflammatory. Silymarin has anti-inflammatory properties, which means it can help reduce inflammation in the body. Chronic inflammation is associated with many health problems, including cardiovascular disease, cancer, and autoimmune disorders.
Skin health. Silymarin has been shown to have anti-inflammatory and antioxidant properties that can help improve skin health. It may help reduce the appearance of age spots, sun damage, and other signs of aging.
Blood sugar. Silymarin has been shown to have hypoglycemic effects, which means it can help lower blood sugar levels. Several studies have demonstrated that silymarin can improve insulin resistance in individuals with type 2 diabetes.
Side-effects
Silymarin may interact with certain medications, including blood-thinning medications, cholesterol-lowering medications, and drugs used to treat diabetes. It is important to speak with a healthcare provider before taking silymarin if you are taking any medications.
Some people may experience allergic reactions to milk thistle extract, particularly those who are allergic to plants in the same family as milk thistle, such as ragweed, chrysanthemums, marigolds, and daisies.
Some individuals may experience digestive issues such as bloating, gas, and diarrhea when taking milk thistle extract.
27. Reduced Coenzyme Q10 (CoQ10, Ubiquinol)
Coenzyme Q10 (CoQ10) is a naturally occurring compound found in every cell of the body, and it plays a crucial role in producing energy for cellular processes. In addition to being produced naturally, it is also available as a dietary supplement. In this summary, we will discuss the benefits and drawbacks of using CoQ10 supplements. Overall, CoQ10 supplements have potential health benefits, particularly in improving cardiovascular health, increasing energy levels, and reducing the effects of aging. Reduced CoQ10, also called Ubiquinol, is the active form of Coenzyme Q10.
Benefits
Improved cardiovascular health. CoQ10 has been shown to improve heart health by reducing inflammation and oxidative stress, which are major risk factors for heart disease. It may also help lower blood pressure and improve blood lipid levels.
Increased energy levels. CoQ10 is a critical component in the production of ATP, the body’s primary energy source. Taking CoQ10 supplements may help improve energy levels and reduce fatigue, particularly in people with conditions that cause low energy levels, such as fibromyalgia and chronic fatigue syndrome.
Anti-aging effects. CoQ10 is a powerful antioxidant that can protect cells from damage caused by free radicals, which can lead to premature aging. CoQ10 supplements have been shown to reduce the appearance of wrinkles and fine lines, as well as improve skin texture and hydration.
Neuroprotective properties. CoQ10 may have neuroprotective effects, as it can cross the blood-brain barrier and help protect brain cells from oxidative stress and inflammation. Some studies have suggested that CoQ10 supplements may improve cognitive function and reduce the risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
Improvements in exercise performance. CoQ10 may improve exercise performance by increasing energy levels and reducing muscle damage caused by oxidative stress. It has also been shown to improve recovery time after exercise.
Side-effects
CoQ10 supplements are generally considered safe and well-tolerated, but some people may experience mild side effects such as upset stomach, diarrhea, and nausea.
CoQ10 may interact with certain medications, including blood thinners and blood pressure medications. It is important to talk to a healthcare provider before starting CoQ10 supplements, especially if you are taking any medications.
CoQ10 supplements can be expensive, and insurance may not cover the cost. This can be a drawback for people who are on a tight budget.
While there is some evidence to suggest that CoQ10 supplements may have health benefits, more research is needed to fully understand its effects. Many studies have been small or of poor quality, and larger, well-designed studies are needed to confirm the benefits of CoQ10 supplements.
28. Pyrroloquinoline Quinone (PQQ)
Pyrroloquinoline Quinone (PQQ) is a compound that is found naturally in some plant-based foods, as well as in the human body. It is also available as a dietary supplement, and has gained popularity in recent years due to its potential health benefits, more research is needed to fully understand its effects on human health.
Benefits
Cognitive function. PQQ has been shown to improve cognitive function, including memory and attention, in both animal and human studies. It is thought to do this by increasing the production of nerve growth factors, which support the growth and development of neurons in the brain.
Energy production. PQQ has been shown to stimulate the production of mitochondria, which are the powerhouses of our cells. By increasing the number and efficiency of mitochondria, PQQ can help to increase energy production and reduce fatigue.
Antioxidant. PQQ is a powerful antioxidant that can help to protect cells from damage caused by free radicals. This makes it potentially useful in the prevention and treatment of a wide range of diseases, including cancer and heart disease.
Anti-inflammatory. PQQ has been shown to reduce inflammation in the body, which is a key factor in many chronic diseases. It does this by inhibiting the activity of certain inflammatory proteins and promoting the production of anti-inflammatory proteins.
Improved sleep. PQQ has been shown to improve sleep quality and reduce sleep disturbances in some people. This may be due to its ability to reduce inflammation and increase the production of nerve growth factors, both of which can help to promote healthy sleep.
Side-effects
Since PQQ is a relatively new supplement, there is limited information on its long-term effects on human health. It is possible that there may be some negative effects associated with long-term use of PQQ, although these have not yet been identified.
PQQ may interact with certain medications, including blood thinners and chemotherapy drugs. It is important to consult with a healthcare provider before taking PQQ if you are taking any medications.
While PQQ is found in some plant-based foods, including parsley and green peppers, the amounts are generally quite low. This means that it may be difficult to get enough PQQ from your diet alone.
PQQ supplements can be relatively expensive, particularly compared to other supplements that are more widely available.
While there is some promising research on the potential benefits of PQQ, much of it has been conducted in animals or in small human studies. More research is needed to fully understand the effects of PQQ in humans, including its long-term safety and efficacy.
29. Hydrolyzed Marine Collagen
Hydrolyzed marine collagen is a type of collagen supplement derived from the skin, bones, and scales of marine animals, such as fish. The collagen is hydrolyzed, which means it is broken down into smaller peptides, making it easier for the body to absorb and use.
Hydrolyzed marine collagen is a popular supplement that offers a variety of health benefits, including improved skin, joint, gut, bone, and muscle health.
Benefits
Skin health. Hydrolyzed marine collagen is a popular supplement for skin health because it provides amino acids that are essential for the production of collagen. Collagen is a protein that gives skin its elasticity and youthful appearance. Studies have shown that hydrolyzed marine collagen can help reduce wrinkles and fine lines, increase skin hydration, and improve skin firmness and elasticity.
Joint health. Hydrolyzed marine collagen contains type II collagen, which is the main component of joint cartilage. This makes it an excellent supplement for joint health. Studies have shown that hydrolyzed marine collagen can help reduce joint pain and stiffness, improve joint function, and reduce the risk of joint degeneration.
Gut health. Hydrolyzed marine collagen contains glycine and proline, two amino acids that are important for gut health. Glycine has been shown to help reduce inflammation in the gut, while proline is involved in the synthesis of collagen and is important for maintaining the integrity of the gut lining.
Bone health. Hydrolyzed marine collagen contains calcium and other minerals that are important for bone health. Studies have shown that hydrolyzed marine collagen can help increase bone density, reduce the risk of osteoporosis, and improve bone strength.
Muscle growth. Hydrolyzed marine collagen is rich in amino acids, which are important for muscle growth and repair. Studies have shown that hydrolyzed marine collagen can help increase muscle mass and strength, reduce muscle damage, and improve recovery after exercise.
Side-effects
Hydrolyzed marine collagen is derived from fish, which can cause allergic reactions in some people. It is important to check with your doctor before taking hydrolyzed marine collagen if you have a fish allergy.
Fish that are used to make hydrolyzed marine collagen may contain heavy metals, such as mercury, which can be harmful to human health. It is important to choose a high-quality supplement from a reputable manufacturer that has been tested for heavy metals.
Hydrolyzed marine collagen may cause digestive issues, such as bloating, constipation, or diarrhea, in some people. This is because it is high in protein and may be difficult to digest for some people. It is important to start with a small dose and gradually increase the dose over time to avoid digestive issues.
Hydrolyzed marine collagen supplements can be expensive compared to other types of collagen supplements. This is because they are derived from high-quality marine sources and undergo a complex manufacturing process to break down the collagen into smaller peptides.
The production of hydrolyzed marine collagen can have environmental impacts, such as overfishing and pollution. It is important to choose a supplement that is sustainably sourced and manufactured in an environmentally responsible manner.
30. Omega-3 (EPA, DHA, ALA)
Omega-3 fatty acids are essential nutrients that the body requires for optimal health. There are three types of omega-3 fatty acids: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA). EPA and DHA are commonly found in fatty fish and fish oil supplements, while ALA is found in plant-based sources such as flaxseed and walnuts.
The benefits of consuming omega-3 fatty acids are numerous. They have been found to reduce inflammation, lower triglyceride levels, and improve heart health. Studies have also shown that they can improve brain function, mood, and cognitive performance.
Benefits
Anti-inflammatory. One of the primary benefits of omega-3 fatty acids is their ability to reduce inflammation. Chronic inflammation has been linked to a wide range of diseases, including heart disease, diabetes, and arthritis. Omega-3s have been found to reduce the production of inflammatory molecules and promote the production of anti-inflammatory molecules, helping to combat chronic inflammation.
Heart health. Omega-3s have also been shown to improve heart health by reducing triglyceride levels, decreasing blood pressure, and reducing the risk of arrhythmias. Studies have found that consuming EPA and DHA can reduce the risk of heart attack, stroke, and sudden cardiac death.
Brain function. Omega-3s have been linked to improved brain function and cognitive performance. Studies have found that people who consume more omega-3s have better cognitive function, memory, and attention. Omega-3s have also been shown to improve mood and reduce symptoms of depression and anxiety.
Anticancer. Studies have found that they can reduce the risk of certain types of cancer, such as breast, prostate, and colon cancer. Omega-3s have also been shown to improve the symptoms of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis.
Side-effects
There are some potential drawbacks to consuming omega-3 fatty acids. One of the main concerns is the potential for contamination with environmental toxins such as mercury, PCBs, and dioxins. However, this can be mitigated by choosing high-quality, purified fish oil supplements and consuming low-mercury fish.
Another concern is the potential for bleeding or bruising, as omega-3s can have a mild blood-thinning effect. Some evidence suggests that high doses of omega-3s may interact with certain medications, such as blood pressure and blood sugar-lowering drugs. These are generally not a concern for most people, but if you are taking medications for these conditions, you should consult with a healthcare provider before taking high doses of omega-3 supplements.
In terms of specific types of omega-3s, EPA and DHA are generally considered the most beneficial. They are more easily absorbed and utilized by the body than ALA, which must be converted to EPA and DHA in the body. While ALA is still beneficial, consuming EPA and DHA directly through fatty fish or fish oil supplements is the most effective way to reap the health benefits of omega-3s.
31. Eucommia bark
Eucommia bark extract is a supplement derived from the bark of the Eucommia ulmoides tree, which is native to China. It has been used in traditional Chinese medicine for centuries to treat a variety of health conditions. The extract is rich in phytochemicals, including lignans and iridoids, which have been associated with various health benefits.
Eucommia ulmoides bark from Chinese Gutta-Percha tree
Eucommia bark extract has the potential to provide a range of health benefits, including joint health, blood pressure management, immune function, sleep quality, sexual function, and anti-aging properties. However, more research is needed to fully understand the potential benefits and drawbacks of using this supplement. Individuals should consult with their healthcare provider before taking Eucommia bark extract and should purchase supplements from reputable sources to ensure purity and potency.
Benefits
Anti-aging. Eucommia bark extract is rich in antioxidants, which can help to protect the body against oxidative stress and the effects of aging. One study found that taking Eucommia bark extract for eight weeks helped to reduce levels of oxidative stress in individuals with metabolic syndrome.
Joint health. Eucommia bark extract has been found to have anti-inflammatory properties, making it a potential treatment for joint pain and inflammation. One study found that Eucommia bark extract helped to alleviate symptoms of osteoarthritis, a common condition that causes joint pain and stiffness.
Blood pressure. Eucommia bark extract has been shown to have blood pressure-lowering effects, making it a potential treatment for hypertension. One study found that taking Eucommia bark extract for eight weeks helped to lower both systolic and diastolic blood pressure in individuals with high blood pressure.
Immune function. Eucommia bark extract has been found to have immune-boosting properties. Studies have shown that it can stimulate the production of white blood cells, which help to fight infections and other diseases.
Healthy sleep. Eucommia bark extract has been found to have sedative properties, making it a potential treatment for insomnia. One study found that taking Eucommia bark extract before bed helped to improve sleep quality in individuals with insomnia.
Sexual function. Eucommia bark extract has been traditionally used as an aphrodisiac in traditional Chinese medicine. Studies have shown that it can increase levels of testosterone and improve sexual function in both men and women.
Side-effects
While there is some research supporting the potential health benefits of Eucommia bark extract, the majority of studies have been conducted in animals or small human trials. More research is needed to fully understand the potential benefits and drawbacks of using this supplement.
Eucommia bark extract is generally considered safe when taken in recommended doses. However, some individuals may experience side effects, such as dizziness, nausea, or upset stomach.
Eucommia bark extract may interact with certain medications, including blood pressure medications, anti-inflammatory drugs, and diabetes medications. Individuals taking these medications should consult with their healthcare provider before taking Eucommia bark extract.
Like many dietary supplements, the quality and purity of Eucommia bark extract supplements may vary. It is important to purchase supplements from reputable sources and to look for products that have been independently tested for purity and potency.
Eucommia bark extract supplements may be more expensive than other dietary supplements. This may be a drawback for some individuals who are on a tight budget or who are looking for more affordable supplement options.
