Ca-AKG plays a key role in the body by activating AMPK signaling and inhibiting the mTOR pathway. AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin (mTOR) are two of the principal pathways that affect aging and lifespan.
One explanation for the longevity effect is that Ca-AKG affects epigenetic processes. The complex molecular system that surrounds the DNA and controls when genes are turned “on” or “off” is known as the epigenome. These chemical modifications regulate gene expression while it does not change the DNA itself. The epigenome becomes progressively dysregulated as we age, which means that some genes that ought to be silent are turned “on”, while others that need to be active, like cancer protective genes, are turned “off”.
With time this dysregulation results in an ever increasing accumulation of epigenetic errors, which we can see as methylation of our epigenome. In recent years scientists have developed biological clocks, such as the Horvath clock, which can measure the aging of our bodies much more exactly than the chronological age. Calcium-alpha-ketoglutarate helps by modulating the methylation of the epigenome.
The metabolism of amino acids and carbohydrates is also connected to the supplement. Our cells’ ability to switch between using amino acids and carbohydrates to make energy decreases as we age. However, Ca-AKG can support cells’ continued maintenance of this metabolic adaptability. Moreover, it functions as an energy source for the cellular mitochondria and enhances mitochondrial health. This is why the compound is popular among athletes and bodybuilders that strive to increase energy and endurance.
Function
People take premium calcium AKG for a variety of reasons.
- Healthspan. Several studies find animals have longer lifespans and healthspans when given Ca-AKG. For instance, in a study of mice it enhanced healthspan by 41% and lifespan by 12%.
- Cellular Energy. The power generators of our cells, the mitochondria, use alpha-ketoglutarate as fuel and the health of the mitochondria is improved by the substance.
- Epigenome. Our epigenome benefits as Ca-AKG can help to control which genes in the epigenome are activated or deactivated.
- Weight. It assist in maintaining weight and in altering our unhealthy white fats into brown fats.
- Anti-Inflammatory. Calcium Alpha-Ketoglutarate decreases levels of inflammatory cytokines and reducing the inflammation caused by senescent cells
Suggested use
The suggested dose is 800 – 1200 mg daily. This corresponds to 2–3 scoops.
Ingredients
Premium Calcium AKG (Calcium Alpha-Ketoglutarate) 99%. No other ingredients.
Disclaimer
The various effects are not guaranteed and results may vary due to several factors between different people.
We strive to ensure the accuracy of the information provided by the manufacturers and recommend that you read all labels and warnings. However, the information is not a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment.
| Quantity: | 100g (3.5oz), 200g (7.1oz), 500g (17.6oz), 1000g (35.3oz) |
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We are proud to offer international shipping services that currently operate in over 100 countries and islands worldwide.
How do you ship packages?
Packages are shipped by various shippers on the weight and size of the product For more information, see our Shipping & Delivery link at the bottom of any page.
Do you ship worldwide?
Yes. We provide free shipping to over 100+ countries around the world. However, there are some locations we are unable to ship to. If you happen to be located in one of those countries we will contact you.
What about customs?
We are not responsible for any custom fees once the items have shipped. By purchasing our products, you consent that one or more packages may be shipped to you and may get custom fees when they arrive to your country. However, please note that we charge the VAT now for a number of countries in advance, which means you do not need to pay this when the parcel arrive.
How long does shipping take?
Shipping time varies by location. These are our estimates:
| Location | *Estimated Shipping Time |
| United States | 7-28 Business days |
| Canada, Europe | 7-28 Business days |
| Australia, New Zealand | 7-28 Business days |
| Central & South America | 12-35 Business days |
| Asia | 12-35 Business days |
| Africa | 12-40 Business days |
*This doesn’t include our 2-5 day processing time.
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Yes, you will receive an email once your order ships that contains your tracking information. If you haven’t received tracking info within 5 days, please contact us.
My tracking says “no information available at the moment”.
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Will my items be sent in one package?
For logistical reasons, items in the same purchase will sometimes be sent in separate packages, even if you’ve specified combined shipping.
If you have any other questions, please contact us and we will do our best to help you out.
RETURNS
Order cancellation
All orders can be cancelled until they are shipped. If your order has been paid and you need to make a change or cancel an order, you must contact us within 12 hours. Once the packaging and shipping process has started, it can no longer be cancelled.
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- If you did not receive the product within the guaranteed time( 45 days not including 2-5 day processing) you can request a refund or a reshipment.
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We do not issue the refund if:
- Your order did not arrive due to factors within your control (i.e. providing the wrong shipping address)
- Your order did not arrive due to exceptional circumstances outside the control of VitaMondo (i.e. not cleared by customs, delayed by a natural disaster).
- Other exceptional circumstances outside the control of
*You can submit refund requests within 15 days after the guaranteed period for delivery (45 days) has expired. You can do it by sending a message on Contact Us page
If you are approved for a refund, then your refund will be processed, and a credit will automatically be applied to your credit card or original method of payment, within 14 days.
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